What happens when another non-Microsoft antivirus/antimalware solution is used? Can you run Microsoft Defender Antivirus alongside another antivirus product? The answers depend on several factors, such as your operating system and whether you're using Microsoft Defender for Endpoint together with your antivirus protection.
(1) On Windows Server, if you're running a non-Microsoft antivirus product, you can uninstall Microsoft Defender Antivirus to prevent conflict. If the device is onboarded to Microsoft Defender for Endpoint, you can use Microsoft Defender Antivirus in passive mode (see below).
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(2) On Windows Server 2019, Windows Server, version 1803 or newer, Windows Server 2016, or Windows Server 2012 R2, Microsoft Defender Antivirus doesn't enter passive mode automatically when you install a non-Microsoft antivirus product. In those cases, set Microsoft Defender Antivirus to passive mode to prevent problems caused by having multiple antivirus products installed on a server. You can set Microsoft Defender Antivirus to passive mode using a registry key as follows:
(3) On Windows Server 2016, Windows Server 2012 R2, Windows Server version 1803 or newer, Windows Server 2019, and Windows Server 2022, if you are using a non-Microsoft antivirus product on an endpoint that is not onboarded to Microsoft Defender for Endpoint, disable/uninstall Microsoft Defender Antivirus manually to prevent problems caused by having multiple antivirus products installed on a server.
Defender for Endpoint includes capabilities that further extend the antivirus protection that is installed on your endpoint. You can benefit from running Microsoft Defender Antivirus alongside another antivirus solution.
For example, Endpoint detection and response (EDR) in block mode provides added protection from malicious artifacts even if Microsoft Defender Antivirus is not the primary antivirus product. Such capabilities require Microsoft Defender Antivirus to be installed and running in passive mode or active mode.
Don't disable, stop, or modify any of the associated services that are used by Microsoft Defender Antivirus, Defender for Endpoint, or the Windows Security app. This recommendation includes the wscsvc, SecurityHealthService, MsSense, Sense, WinDefend, or MsMpEng services and processes. Manually modifying these services can cause severe instability on your devices and can make your network vulnerable. Disabling, stopping, or modifying those services can also cause problems when using non-Microsoft antivirus solutions and how their information is displayed in the Windows Security app.
In Defender for Endpoint, you can turn EDR in block mode on, even if Microsoft Defender Antivirus isn't your primary antivirus solution. EDR in block mode detects and remediate malicious items that are found on the device (post breach). To learn more, see EDR in block mode.
In active mode, Microsoft Defender Antivirus is used as the antivirus app on the machine. Settings that are configured by using Configuration Manager, Group Policy, Microsoft Intune, or other management products will apply. Files are scanned, threats are remediated, and detection information is reported in your configuration tool (such as in the Microsoft Endpoint Manager admin center or the Microsoft Defender Antivirus app on the endpoint).
In passive mode, Microsoft Defender Antivirus isn't used as the antivirus app, and threats are not remediated by Microsoft Defender Antivirus. However, threats can be remediated by Endpoint detection and response (EDR) in block mode. Files are scanned by EDR, and reports are provided for threat detections that are shared with the Defender for Endpoint service. You might see alerts showing Microsoft Defender Antivirus as a source, even when Microsoft Defender Antivirus is in passive mode.
When Microsoft Defender Antivirus is in passive mode, you can still manage updates for Microsoft Defender Antivirus; however, you can't move Microsoft Defender Antivirus into active mode if your devices have a non-Microsoft antivirus product that is providing real-time protection from malware.
Make sure to get your antivirus and antimalware updates, even if Microsoft Defender Antivirus is running in passive mode. See Manage Microsoft Defender Antivirus updates and apply baselines.Note that passive mode is only supported on Windows Server 2012 R2 & 2016 when the machine is onboarded using the modern, unified solution.
When disabled or uninstalled, Microsoft Defender Antivirus isn't used as the antivirus app. Files aren't scanned and threats aren't remediated. Disabling or uninstalling Microsoft Defender Antivirus isn't recommended in general; if possible, keep Microsoft Defender Antivirus in passive mode if you're using a non-Microsoft antimalware/antivirus solution.
In cases where Microsoft Defender Antivirus is disabled automatically, it can be re-enabled automatically if the non-Microsoft antivirus/antimalware product expires, is uninstalled, or otherwise stops providing real-time protection from viruses, malware, or other threats. The automatic re-enabling of Microsoft Defender Antivirus helps to ensure that antivirus protection is maintained on your endpoints.
Main version: 3.0.1.1Update versions: 16.2.22.1/595911.2016062223/7.66019/6858364.20160622, 16.2.22.1/598338.2016071117/7.66278/7056588.20160711Last 6 tests: 5 passed, 0 failed, 1 no entryLast 12 tests: 10 passed, 0 failed, 2 no entryItW on demand: 100.00% ItW on access: 100.00%False positives: 0 Stability: Solid
Main version: 4.0.0.10011Update versions: 2016.06.22.01, 2016.07.12.01, 2016.07.18.01, 2016.07.28.01Last 6 tests: 3 passed, 0 failed, 3 no entryLast 12 tests: 3 passed, 0 failed, 9 no entryItW on demand: 100.00% ItW on access: 100.00%False positives: 0 Stability: Solid
NANO managed its first VB100 pass in the last (June 2016) test, and returns for another try straight away. The product is clear and easy to use, and proved remarkably stable under the heavy strain of our testing processes, showing no signs of stability issues at all. Detection was a little below par, and showed a steady decrease through the test sets, but the certification sets were properly dealt with and NANO can be proud of its second VB100 award from two attempts.
Next up, in a slight re-organization of our normal pattern of platforms, will be another visit to Windows 7, squeezed in to give Microsoft time to release the much-anticipated 2016 Server, the big brother to Windows 10, which looks likely to give us another set of headaches.
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